Scatter Plot from Scientific Research

Strip plots visualizing the two rounds of directed evolution conducted for each antibody. Each point represents an IgG or Fab variant plotted according to the fold change in Kd from wild-type on the y axis and jitter on the x axis; a gray, dashed line is drawn at a fold change of 1, and the wild-type point is colored gray. MEDI8852 variants were screened against HA H4 Hubei; MEDI8852 UCA variants against HA H1 Solomon; mAb114 and mAb114 UCA variants against ebolavirus GP; S309 variants against Wuhan-Hu-1 S-6P; and REGN10987 and C143 variants against Beta S-6P.

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