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Schematic of the mammalian expression of modular constructs coding for self-assembling encapsulin monomers with N-terminal fusions of metallothioneins (M) and C-terminal surface modifications for targeting (EMcapsulins). Expression of the EMcapsulin variants results in the auto-assembly of hollow protein nanospheres with different triangulation numbers (T), distinct diameters and one to three concatenated copies of M facing the lumen of the porous protein shells.

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