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Transcription dynamics of the premature (unspliced) and mature (spliced) mRNAs are governed by the transcription ( α ), splicing ( β ) and degradation ( γ ) rates. Multi-kinetics genes involve multiple-lineage and/or multi-stage transitions of the cellular states; hence, cell-dependent rates ( α , β , γ ) t are required to accurately capture the transcription dynamics of those genes. In the illustration, the ( α , β , γ ) t for cell t are computed by locating the future state cell in the neighboring cells of t (‘local environment’), assuming that the cells in the local environment share the same ( α , β , γ ).

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