Line Plot from Scientific Research

DMS reactivities were obtained for the near full-length genome from two overlapping amplicons of approximately 4 kb. Virion (blue) and cell (red) DMS reactivities shown are smoothed over a dynamic window containing 20 A or C nucleotides. DMS reactivity difference between virion and cell is shown in green (mean virion RNA – mean cell RNA). Pearson's correlations of the 20-nt window between the virion and cell DMS reactivities are shown in black. Genome position is shown on the x axis and the position of the frameshift element and the RRE is highlighted with dotted lines. Positions of HIV-1 ORFs are represented as boxes at the top of the plot.

DOI