Violin Plot from Scientific Research

The number of repair foci (53BP1 or BRCA1) as detected by STED in cells with or without Cas9 ('+Cas9' or '-Cas9', respectively), with or without Ku-60648 ('KU' versus 'nD', respectively), targeting 126 genome-wide sites with a multi-target gRNA. N = 98 cells from four biologically independent replicates, P = 4.44 x 10 -10 using two-sided Wilcoxon rank-sum test between '-Cas9' and '+Cas9'. Difference in no. of foci in each group was not significant (left, P = 0.15; right, P = 0.95).

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