Line Plot from Scientific Research

3D polymer simulation reveals a large discrepancy between the kinetics of synapsis mediated by diffusion alone and the synapsis kinetics determined experimentally. The shaded area around the cumulative probability curve (calculated from 2223 DSB events) represents the 95% confidence interval of the cumulative probability estimated with DvoretzkyKieferWolfowitz inequality. The vertical dash lines indicate the experimentally determined synapsis time to reach 95% and the simulated synapsis time by passive diffusion alone to reach 95%, respectively.

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