Metabolic activity expressed by XTT of A. fumigatus biolfilm treated with VOR or CAS alone and combinations of BRI + VOR and BRI + CAS. Biofilm was formed for 24 h of incubation at 37 °C. After this period 50 µL of fresh MM containing CAS, VOR or a combination of VOR + CAS or CAS + BRI were added to the biofilm to reach the final concentration as indicated and incubated for further 12 h at 37 °C. Untreated biofilm was used as a positive control. The graphic shows the value of 9 technical replicates from three independent experiments ± SD deviation ( n = 3; 2way ANOVA, Tukey´s post-test; * p < 0.05, ** p < 0.005, and **** p < 0.0001).
