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Quantification of conservative replication in U2OS WT and EXD2 -/- as determined by two-replication round segregated CO-FISH using SpO and FITC-labelled PNA FISH probes specific to the telomeric repeat sequences. Cells treated with siRNA targeting SMARCAL1 or MUS81, or were treated with control siRNA targeting Luciferase, as indicated ( n = 75 metaphases examined over 3 independent experiments, statistical significance was determined by two-sided MannWhitney analysis, bars represent +/- SEM).

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