Histogram from Scientific Research

Rate of gestational weight gain during the third trimester (RGWG-T3) and offspring risk for neurodevelopment disorders according to category of maternal BMI at first antenatal visit. Histograms illustrate the distribution of RGWG-T3 for those included in each analysis. Adjusted estimates are shown for any NDD, ASD, ADHD, and ID. The curved solid black line represents the hazard ratio (HR) calculated through restricted cubic splines models with 3 knots. The grey bands represent the 95% CI. A reference line is included for an HR of 1.00. P- values for analyses are shown for a Wald test with a null hypothesis that all spline terms were jointly equal to 0, as a test of whether the exposure was generally associated with the outcome. The model was adjusted for birth year, childs sex, maternal age at birth, household income quintiles at birth, maternal education level, parental birth region, interpregnancy interval, maternal psychiatric history, maternal smoking during pregnancy, and maternal BMI at first antenatal visit (only in the full cohort analysis). Note that the y -scale differs for ID compared to the other outcomes

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