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We further analyzed the promoter upstream 2-kb regions to see whether there were some strongly correlated genomic areas, the potential cis-regulators for the promoters. The calculation details could be found on the method. Each pixel in the heatmap was 50 bp length. Some prompters strongly correlated with their proximal regions (black box), suggesting that these proximal regions synchronized with the corresponding promoters in the H3K27me3 regulation.
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