We selected two genomic regions (chr20:31,866,019 ~ 31,871,019 gene Dsup15 , chr20:44,650,712 ~ 44,655,712 gene Ada ), which included the documented promoters and enhancers. Each pixel in the heatmap means the 50 bp length. The correlation index calculated based on method. The higher correlation index (red) between two regions suggested the accordant changes. We could observe the high correlation (black square) between the enhancers and promoters. The lower black curves indicated the interaction signals in Hi-C data. The physically interacted regions (Hi-C) also supported the high H3K27me3 correlation.