H3K27me3 heterogeneity pattern of genetic promoters in Chr20 (method in Fig. S 13 ). Each pixel on each row corresponds to methylation bin density of each individual DNA molecule, and each row corresponds to each genetic promoter (2 kb upstream of the transcription start site included most of the promoter regions). The methylation bin density was ranked from low to high (left to right). The blue, white-yellow, red corresponded matched the heavy, medium, light state. The left green bar (expr) showed the average expression value (expected count) of the corresponding gene clusters. Cluster 3, Cluster 4 with high RNA expression level were highlighted by green box. Cluster 1, Cluster 5 with low RNA expression level were highlighted by purple box.
