Correlation matrix showing the Pearson correlation coefficient for the relationship between HMW concentration and the probability of observing a burst event in Dox-treated rTg4510 mice (values at y = 4 ms are the same as in I) across all examined intra-burst ISI thresholds (4–12 ms, y axis) and burst complexity values (number of spikes per burst, 2–≥5, x axis). Cold colors indicate a negative correlation. Data from N= 6 mice for each comparison. Note the progressively stronger negative correlation for faster and more complex burst events, where asterisks indicate correlation p< 0.05 (uncorrected for multiple comparisons). See Table S1 for LME modeling, indicating a significant effect of HMW tau, but not LMW, on burst event probability. See also Figure S2.
