Quantification showing a significant reduction in burst index of rTg4510 and APP/PS1-rTg4510 neurons versus those from WTs. LME model with WT as reference level; fixed effects coefficients: intercept, 0.10 [0.09 0.12, 95% CI], tStat = 12.15,p< 0.0001; APP/PS1, 0.04 [0.011 0.067, 95% CI], tStat = 2.79,p= 0.005; rTg4510, -0.076 [-0.11-0.04, 95% CI], tStat = -4.44,p< 0.0001; APP/PS1-rTg4510, -0.065 [-0.1-0.03, 95% CI], tStat = -3.77,p= 0.0002 (dF = 371 in all cases). Post hoc pairwise comparisons with Bonferroni correction for multiple comparisons. Black bars indicate medians with each datapoint denoting a single neuron; cell numbers given in (A) across 4 (WT) or 3 mice per genotype.
