Left, example 20-s recording of LFP activity in CA1 and concurrent neuronal spiking activity raster of six putative excitatory CA1 neurons, with black markers indicating single spikes and red markers indicating burst-related spikes, in a WT mouse and APP/PS1-rTg4510 mouse with both human Ab and tau. Right, outcomes of clustering spike waveform parameters from units within putative CA1 pyramidal layer (Str. Pyr., seeFigure S1A), using Gaussian-mixture modeling (GMM). Far right, averaged spike waveforms for each cluster, with cluster 2 (magenta) being associated with the fastest waveform dynamics and classified as putative fast-spiking inhibitory interneurons and cluster 1 (black) being classified as (primarily) putative excitatory neurons (colors as in left panel). See alsoFigure S1.
