Venn Diagram from Scientific Research

Outline of connective pathway analysis: (1) identification of genes that belong to a pathway; (2) mapping DEGs on that pathway; (3) pairwise comparison of pathway-associated DEGs; (4) assessment of pathway-associated DEGs overlap (Jaccard Index); (5) examples of two extreme situations, pathways X1 (green) and X2 (orange) have a high overlap of DEGs but not X1 (green) and X3 (purple); (6) hierarchical clustering using the 1-Jaccard index as distance matrix; and (7) dendrogram transformation into a tree-like structure.

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