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The proportion of participants with titer (ID50 >= 10) to a specific GII.4 variant was determined by age, year, and variant in sera collected from children aged one to six years between 2008 and 2012. Only sera tested against all four variants were included in the analyses (n = 656). The dashed line represents the proportion of responders in all years of sample collection combined. See also Figure S2 and Table S1.
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