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Simulations of in vitro CSF-cN stimulation. (A) Schematic view of the in vitro stimulation experimental setup combining calcium imaging at 40x, 5 Hz and stimulation of CSF-cN with a gradient of molecule. (A') Simulation of the concentration of molecule sensed by CSF-cN for a range of coefficients of diffusion (from 1 x 10-10 to 2 x 10-9 m2/s); [C]i corresponds to initial concentration in the stimulation pipette. (A'') Simulation of the concentration of pneumolysin (Ply), dimethyl disulfide (DMDS), and 2-pentanone; coefficients of diffusion: 1 x 10-10, 1 x 10-9, and 2 x 10-9 m2/s, respectively; [C]i corresponds to initial concentration within the stimulation pipette.

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