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Experimental design to generate adult knockdown (KD) mice and to examine the effect of target gene suppression on disease progression of tauopathy mice. AAV vectors for tetracycline-inducible expression of shRNA are delivered into the mouse brain by ICV injection at postnatal day 0. TRE, TTA response element; CBA, chicken -actin promoter; TTA, tetracycline-transactivator; T2A, 2A self-cleaving peptides sequences.

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