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Screen validation. H1-Cas9 SNaPs were transduced with individual gRNAs and exposed to ZIKV-Ug (MOI = 1). Quantification at 54 hpi. Dashed line denotes adjusted p value < 0.05 (E-H) or infectivity levels for non-targeting gRNA controls (J). One-way ANOVA with Dunnett’s test for multiple comparisons. Data presented as mean SD. N.S. = not significant,****p < 0.0001.
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