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Wild-type (WT) male mice were administered ethanol (5 g/kg, oral gavage) followed 1 h later by i.p. injection of vehicle or FGF21 at the indicated doses. Loss of righting reflex (LORR) duration was measured after FGF21 or vehicle administration (n = 5–6 mice/group). Data represent the mean ± SEM.*p < 0.05,**p < 0.01,***p < 0.001 compared to vehicle by one-way ANOVA.

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