Cross-omic interactions modified by MetBMI and days in the program. For each of the 608,856 pairwise relationships of plasma analytes (766 metabolites, 274 proteomics and 64 clinical laboratory tests), the baseline relationship between analyte–analyte pair and MetBMI within the Arivale subcohort (Fig. 5a ; 608 participants) was assessed using their interaction term in each GLM ( Methods ) while adjusting multiple testing with the Benjamini–Hochberg method. The 100 analyte–analyte pairs (82 metabolites, 33 proteins and 16 clinical laboratory tests) that were significantly modified by the baseline MetBMI are presented. For each of these 100 pairs, the longitudinal relationship between analyte–analyte pair and days in the program within the metabolically obese group (that is, the baseline obese MetBMI class; 182 participants) was further assessed using their interaction term in each GEE ( Methods ) while adjusting multiple testing with the Benjamini–Hochberg method. The 27 analyte–analyte pairs (21 metabolites, three proteins and three clinical laboratory tests) that were significantly modified by days in the program are highlighted by line width and label font size. N.A., not available. All exact values of test summaries are found in Supplementary Data 7
