Difference in ΔBMI between clinically defined metabolic health conditions within the normal or obese BMI class. Each comparison value indicates adjusted P value, calculated from OLS linear regression with BMI, sex, age and ancestry principal components as covariates while adjusting multiple testing with the Benjamini–Hochberg method across the eight (2 BMI classes × 4 omics categories) regressions. b , d , e , Data: the standard box plot ( Methods ); n = 373 ( b , Healthy in Normal), 49 ( b , Unhealthy in Normal), 208 ( b , Healthy in Obese) or 241 ( b , Unhealthy in Obese) participants (see Supplementary Data 6 for each sample size in d and e ). All exact values of test summaries are found in Supplementary Data 6 and 10 .
