Difference in the obesity-related clinical blood marker ( d ) or BMI-associated physiological feature ( e ) between the matched and mismatched groups within the normal or obese BMI class. Each comparison value indicates adjusted P value, calculated from OLS linear regression with BMI, sex, age and ancestry principal components as covariates while adjusting multiple testing with the Benjamini–Hochberg method across the 40 ( d , 2 BMI classes × 2 omics categories × 10 markers) or 216 ( e , 2 BMI classes × 4 omics categories × 27 features) regressions. Four of the 27 features that were significantly associated with BMI (Fig. 1c ) are representatively presented in e , and the other results are found in Supplementary Data 6 . 25(OH)D, 25-hydroxyvitamin D; a.u., arbitrary units. b , d , e , Data: the standard box plot ( Methods ); n = 373 ( b , Healthy in Normal), 49 ( b , Unhealthy in Normal), 208 ( b , Healthy in Obese) or 241 ( b , Unhealthy in Obese) participants (see Supplementary Data 6 for each sample size in d and e ). All exact values of test summaries are found in Supplementary Data 6 and 10 .
