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Model: MERVL-mediated totipotent-to-pluripotent transition during preimplantation development. MERVL and adjacent intergenic regions are expressed in a zygote and two-cell-stage-specific manner and suppresses a subset of 2C gene expressions through an unknown mechanism to facilitate the totipotent-to-pluripotent transition. KD of MERVL transcript compromises these processes and results in retention of two-cell-like states and embryonic lethality. Data for panels a , b , d , e and g are available as source data.
#Workflow#Flowchart#MERVL#Totipotent-to-pluripotent transition#Preimplantation development#2C gene expressions
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