Scatter Plot from Scientific Research

Model of mutation accumulation during neuroblastoma growth. Neutral SSNVs are continuously acquired at rate mu eff , defined as the number of neutral mutations per effective division (where one effective division produces two surviving daughter cells). By fitting the model to the measured VAF distribution, an estimate for mu eff is obtained on the level of individual tumors (subsetting on cases with sufficient data quality and excluding tumors with evidence for subclonal selection during tumor growth).

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