Line Step from Scientific Research

Mutation densities of ECA and MRCA for the validation cohort. Top, cumulative SSNV densities of the ECA (dark green) and MRCA (light green) of primary tumors classified as either early-MRCA neuroblastoma (n = 22). d , e , Solid lines represent maximum-likelihood estimates and shaded areas represent 95% confidence intervals obtained by nonparametric bootstrapping of chromosomal segments. Bottom, timing of pervasive chromosomal gains; segments compatible with both ECA and MRCA were classified as early, with subclonal gains excluded.

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