Histogram from Scientific Research

Densities of non-amplified ( d ) and amplified ( e ) clonal mutations on genomic segments of length ≥10 7 bp for the tumor shown in a . Dashed line indicates kernel-density estimate of the distribution of non-amplified clonal mutations shown in d . Chromosomal segments of equal copy number were combined into single genomic segments, and Holm-corrected, one-sided P values were computed based on negative binomial distribution (exact P values provided in Source Data ).

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