Line Plot from Scientific Research

Toy model of mixing immune-edited and immune-escaped tumors. It is possible to estimate immune dN/dS by aggregating all mutations and generate a single cohort estimate or to estimate a distribution of values per patient. In both cases, we hypothesize that mixing escaped with edited tumors leads to loss of immune selection signals reflected by immune dN/dS values closer to one (depicted as red dashed lines in the figure).

DOI