Scatter Plot from Scientific Research

Gene selection for the targeted sequencing panel. Genes were selected based on a combination of previous association statistics (SCHEMA), gTADA rankings and GWAS associations. Specially, we included: (1) genes in the top 100 based on the gTADA rank and/or the SCHEMA P value (top 100 in SCHEMA and gTADA, top 100 in SCHEMA alone and top 100 in gTADA alone; total n = 133 genes); (2) genes with evidence for association with SCZ in both GWASs and SCHEMA (special GWAS genes; n = 4 genes); and (3) an additional 24 genes that had the best 24 gTADA rankings of the remaining genes with a burden P value of <0.05, to fill up the target panel. The x axis shows the gene-level P value using SCHEMA interim data, based on which the panel was constructed (different from the final published version). The y axis shows the gTADA rank of genes. Only the top 500 genes are plotted for a clear display. Some highly ranked genes were excluded (gray dots) due to logistic issues during panel construction.

DOI