UMAP from Scientific Research
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Differentiation along a particular lineage involves upregulation of lineage-defining genes and downregulation of stemness genes or genes that define alternative lineages. Left: RNA modality UMAP of CD34 bone marrow, with erythroid lineage cells highlighted. Middle: UMAPs colored by expression of erythroid gene KLF1 and stem gene LPCAT2 , which are upregulated and downregulated, respectively, during erythroid differentiation. Right: accessibility landscapes of KLF1 (top) and LPCAT2 (bottom), aggregated by cell type, during erythroid differentiation.
#UMAP#Line Plot#Differentiation#Lineage-defining genes#Stemness genes#RNA modality UMAP#Bone marrow#Erythroid lineage cells#Erythroid gene#Stem gene#Accessibility landscapes#Cell type
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