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EndoS, SpeB and IdeS are secreted enzymes from S. pyogenes that can act on IgG antibodies. SpeB and IdeS are proteases that hydrolyze the flexible hinge region between residues 220 to 248 of the IgG antibody 96 , 97 , 98 . EndoS is an ENGase that hydrolyze the -1,4 linkage between the first two GlcNAcs of the CT N -glycans on the Fc region of IgG antibodies. The three enzymes inactivate IgG antibodies against S. pyogenes .
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