Workflow from Scientific Research

The potential role of 1,5-AG in the progression of pre-B acute lymphocytic leukemia. Enhanced anaerobic glycolysis of pre-B ALL cells was observed with 1,5-AG by promotion of cell viability and cell cycle, and increased lactate accumulation by upregulation of PDK4. Meanwhile, the elevated levels of glycolysis increased the levels of intracellular ROS, which in turn activated the MAPK/ERK pathway, thus, promoting the progression of leukemia. Both siPDK4 and the treatment of antioxidants were effective in the prevention of 1,5-AG-mediated malignant progression of pre-B ALL

DOI