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Washed human platelets were incubated in the absence (basal) or in the presence of MRS2179 (10 M), MRS2279 (10 M), or MRS2500 (10 M) for 2 h and IP1 accumulation was quantified. Data represent the mean s.d. of 8 healthy donors and are expressed as the percentage of matched basal values. The statistical comparison was assessed using Kruskal-Wallis test followed by Dunn’s post-tests (* p < 0.05; ** p < 0.01; **** p < 0.0001)
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