Line Plot from Scientific Research

Dose-response curve was performed in HEK293T cells co-expressing Gaq-RLuc8, GFP2-Gγ2, Gβ1, and P2Y 1 -R after stimulation or not with increasing concentrations of MRS2179 for 1 min. Results are expressed as the difference in the BRET signal measured in the presence and in the absence of MRS2179. Data represent the mean ± s.e.m. of five independent experiments. Statistical significance between unstimulated and stimulated cells was assessed by one-way ANOVA followed by Sidak’s post-tests (* p < 0.05; *** p < 0.001; **** p < 0.0001). Maximal efficacy (Emax ± s.e.m.) and potency (EC50 and pEC50 ± s.e.m.) of MRS2179 are indicated in the inset.

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