RBM sequence alignment of the indicated merbecoviruses. MOW15-22 and PnNL2018B-specific insertions and disulfide are indicated in red and yellow, respectively. Red/black asterisks, residues crucial for NeoCoV interactions withP.pipACE2 that are conserved/not conserved in MOW15-22 and PnNL2018B. The MOW15-22 residue numbering is shown.