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qPCR expression analysis of TREM2 isoforms in brain cortical tissue of 7-month-old control and 5xFAD mice expressing human TREM2 gene (B6 hT2 and 5xFAD hT2). Animals from both sexes were analyzed together (3 males and 1 female B6 hT2 ; 3 males and 3 females 5xFAD hT2). Statistical analysis was performed by the Student t-test. Data are expressed as mean values ± SEM (** P < 0.01; *** P < 0.001)

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