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Schematic illustration that the collateral activity of RfxCas13d cleaves 28s rRNA into two fragments, leading to translation attenuation and activation of ZAKα-p38/JNK-IEGs pathway. i , j Two-tail unpaired t test. Significance levels are noted as *** P < 0.001, **** P < 0.0001, or ns ( P > 0.05). All values are presented as mean ± SEM

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