Gel from Scientific Research

Open access visualization of Gel, Western Blot, SPPL3, B3GNT5, Lysosome
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Western blot analysis showing that SPPL3 mediates B3GNT5 cleavage and subsequent degradation by the lysosome. Bafilomycin A1 (BafA1) and chloroquine were used to inhibit the lysosome. Full-length (FL) B3GNT5 protein is readily detected in MEC and SNU878 SPPL3-deficient cells. The cleaved form of the B3GNT5 protein is readily detected in control cells with lysosome inhibition. Accumulation of LC3 was used as indicator for lysosome inhibition. n = 3.

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