Jitter plot of CIC motif enrichment in Atxn1154Q/2Q and Atxn1154Q[V591A;S602D]/2Q DEGs by brain region. The black dot indicates % DEGs with CIC motif within 1 kb of the transcriptional start site from each respective RNA-seq dataset. Colored jitter plot represents the % of non-DEGs with motif calculated over 10,000 random iterations. For each assay, a minimum of 8 mice were used unless otherwise specified. Two-way ANOVA with Tukey’s multiple comparisons was used for (B); one-way ANOVAs with Tukey’s multiple comparisons test were used for (C) and (D); Mantel-Cox log-rank was used for (E). In each case,*,**,***,****, and ns denote p < 0.05, p < 0.01, p < 0.001, p < 0.0001, and p > 0.05, respectively. All data are represented as mean SEM. See also Figure S1.
