Boxplots showing the comparison of H3K4me3, H3K27me3, H3K9me3 ChIP-seq profiles, expression levels (FPKM) and DNA methylation levels between proximal and distal genes relative to LTR5_Hs/HERVK subfamily (left panel) and LTR14/HERVK subfamily (right panel) in male (top panel) and female (bottom panel) hPGCs at early stage. For male, Wk10 and Wk23 hPGC samples are represented as early and late stage, respectively; for female, Wk10 and Wk21 hPGC samples are represented as early and late stage, respectively. F female, M male, De-methyl demethylated. Student’s t test is performed to examine the significant statistical difference between two groups of data in boxplots in ( a , c and e ). * P < 0.05, ** P < 0.01, *** P < 0.001, n.s. not significant.
