Protein Structure from Scientific Research

Comparison of the structures of DAs in different HER dimers. From left to right: EGFR–EGF (PDB code: 1IVO), dEGFR–Spitz (PDB code: 3LTG), EGFR–EREG (PDB code: 5WB7), EGFR–EGF/HER2 (this study), and HER2/HER3–NRG-1β (PDB code: 7MN5). The DAs of the symmetric EGFR dimer exhibit the same conformation. For asymmetric dimers, the DAs of the unbent subunit pack closely with its counterpart, mimicking that of the symmetric EGFR dimer, whereas those of the bent subunit display various structures. The distances between DAs of the bent subunits and their partners are indicated.

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