Microscopy from Scientific Research

HeLa cells were transduced with lentivirus to express eGFP-Htt-polyQ constructs of mutant Huntingtin exon 1 composed of N17, QN and C38 domains. Four days following transduction, cells infected with eGFP-Htt-Q31 had a diffuse GFP signal, whereas bright micrometre-scale puncta were evident in those infected with eGFP-Htt-Q73.

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