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Myh6 cDNAs, amplified from RNAs extracted from each cardiac chamber of R403Q-129SvEv/S4 mice, treated with low (1.1 x 10 12 vg kg -1 ; n = 1 male, 2 females), medium (5.4 x 10 12 vg kg -1 ; n = 3 females) and high (2.2 x 10 13 vg kg -1 ; n = 2 females) doses of AAV9-Cas9 for 18-33 weeks. The percentage of inactivation of the pathogenic variant R403Q was calculated as: (1 - (total number of R403Q reads, divided by total number of WT reads)) multiplied by 100.

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