Microscopy from Scientific Research

Left: representative Masson-trichrome-stained LV and RV histological sections from WT 129SvEv/S4 male (left), treated (two doses of AAV9 ABE8e) male R403Q-129SvEv/S4 (middle) and untreated R403Q-129SvEv/S4 (right) male mice. Collagen deposition (blue staining) within regions of myocardial fibrosis was prominent in the untreated but minimal in the treated mouse and WT mice. (Scale bar, 1 mm). Right panel: quantification of fibrosis from Masson-trichrome-stained ventricular sections (five per mouse) from untreated ( n = 5 males) and treated ( n = 3 males; two doses) of AAV9 ABE8e R403Q-129SvEv/S4 mice.

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