Network from Scientific Research

Shared modules as a network, nodes are gene modules associated with different immune-related traits colored blue or red for the two trait subgroups; edges represent a high degree of overlap at the gene level (Jaccard index > 0.7). Gene modules linked to different traits are given in black circles. Gene modules are linked with the yellow node ‘ChEMBL-drugs’ when they contain targets for drugs in clinical trials (phases III and IV, ChEMBL); linked with green nodes when they are enriched in genes with clinical variants for a given disease; and linked with purple nodes when they are enriched for the corresponding KO phenotypes (one-sided Fisher’s exact test, adjusted P < 0.05).

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