Heatmap showing the overlap between gene modules across traits (color-coded as in Fig. 3a,c,d). The GOBP description is based on the results of a GOBP enrichment test (one-sided Fisher’s exact test, BH adjustment, Methods). The heatmap in the right-hand panel shows the gene set enrichment analysis carried out on the expression data from different tissues extracted from Human Protein Atlas (HPA) for the gene modules in blue (two-sided Kolmogorov–Smirnov test, Methods). After BH adjustment for multiple testing, the P value of the test was log transformed and given a positive value if the median distribution for the foreground was higher than the background and a negative value if it was lower.
