Simplified heatmap of the clusters in a concerning bonerelated and fasciitis traits. The represented network includes genes from the modules indicated in blue letters and the represented interactions have been filtered for visualization ( Methods ). Blue nodes, relevant mouse KO phenotypes; green nodes, diseases with clinical variants enriched in this gene module; red nodes, drugs in clinical trials. Genes linked to blue, green or yellow nodes have the linked mouse phenotypes, clinical variants in the linked disease or are targets of the linked drug. Genes that are the targets of drugs in clinical trials have yellow nodes. GWAS-linked genes (L2G score > 0.5) have borders colored in an orange to red gradient (count of GWAS-linked traits).
