Heatmap showing the overlap between gene modules across traits. Traits were clustered using hierarchical clustering ( Methods ) and subgroups were defined by a cutoff of 0.6 average correlation coefficient. A module was considered the same across different traits when most genes are in common (Jaccard index > 0.7). Significant traitmodule relations are marked in yellow or pink, with yellow indicating modules overrepresented in one of the subgroups of traits (onesided Fishers exact test, adjusted P < 0.05) and pink otherwise. The heatmap in the right-hand panel shows the number of genes in modules from each subgroup of traits that are drug targets (phase III or higher, ChEMBL database), linked with clinical variants (ClinVar database) or with mouse KO phenotypes (International Mouse Phenotyping Consortium database).
