Amino acid sequence alignment of one representative S glycoprotein from each of the six merbecovirus clades focused on the epitopes recognized by the S2P6 (green) and B6 (navy) stem helix-directed antibodies as well as the 76E1 (cyan) fusion peptide-directed antibodies. Residues indicated with a red background are strictly conserved, whereas residues indicated with a white background show variability. The residue numbering corresponds to HKU5-19s. Alignment and visualization were done using ESPript.73 See alsoFigure S6andTable S1.
